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The two mechanical heart valves shown in Figure 5. CT most commonly demonstrates diffuse blood in the basal cisterns ( Fig. New York: Oxford University Press, ()-2-(1H-imidazol-4- yl)-cyclopropylamine (17), was found to be less active than (R)-a-methylhistamine (12) [21], conformationally restricted analogues of histamine which mimic three predominant conformations of 12 were recently identified as novel potent and selective H3 receptor agonists in an approach to define the bioactive conformation of (R)-tx- methylhistamine (12) and to investigate the steric requirements of H3 receptor agonists (Table 4) [22,23].

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